Apremilast intermediate

Apremilast intermediate - Names and Identifiers

Name	Apremilast intermediate
Synonyms	Apremilast int Apremilast Impurity 42 Apremilast intermediate 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine 1.1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine 1-(3-Ethoxy-4-methoxyphenyl)-2- (methylsulofonyl)ethan-1-amine 3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine 3-Ethoxy-4-Methoxy-alpha-[(Methylsulfonyl)Methyl]-benzeneMethanaMine
CAS	253168-94-4
EINECS	807-312-3

Apremilast intermediate - Physico-chemical Properties

Molecular Formula	C12H19NO4S
Molar Mass	273.35
Density	1.195±0.06 g/cm3(Predicted)
Melting Point	120 °C
Boling Point	469.6±45.0 °C(Predicted)
Solubility	Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli
Appearance	Solid
Color	White to Off-White
pKa	6.84±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Use	Intermediate

Apremilast intermediate - Introduction

Apremilast intermediate(Intermediates of Appel) is a class of Intermediates commonly used in organic chemistry, and its main feature is that it contains Cl3P (phosphine trichloride) functional groups. Such intermediates are typically used in alkylation reactions.

Properties of Apremilast intermediate:

1. Appearance: generally colorless or light yellow solid
2. Stability: relatively stable at room temperature, but easy to hydrolyze
3. Flammability: Dangerous reactions may occur when flammable materials are encountered

Purpose of the Apremilast intermediate:

1. Alkylation reaction: Apremilast intermediate can react with alcohol, phenol, Amine and other compounds to generate the corresponding alkylation product.
2. Transformation of functional groups: Apremilast intermediate can be reduced, oxidized, substituted and other reactions by other reagents, thus converting into target functional groups.

The preparation method of Apremilast intermediate:

Generally, Apremilast intermediate can be prepared by reacting phosphine trichloride with thionyl chloride (SOCl2) under appropriate conditions.

Security information for Apremilast intermediate:

1. Toxicity: Apremilast intermediate has certain toxicity to human body, and may be harmful by inhalation, ingestion or contact with skin.
2. Corrosive: Apremilast intermediate is corrosive and should be careful to avoid contact with skin and eyes.
3. Fire hazard: Apremilast intermediate may react dangerously when in contact with flammable materials, and should avoid mixing with flammable materials for storage.

When using Apremilast intermediate, it is recommended to take appropriate safety measures, such as wearing protective gloves, goggles and protective clothing, and pay attention to a well-ventilated laboratory environment when operating.

Last Update：2024-04-09 15:16:34